The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells.

2 E–L) and this was reflected by a highly significant negative correlation between T cell infiltrates with age and disease duration ( Supplementary Fig. 2 A and B).

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Overall, the percentage of apoptotic CD8+ T cells was higher in acute/relapsing-remitting multiple sclerosis lesions (median 3.19; range 0–17%) in comparison to lesions of progressive multiple sclerosis (median: 1.3, range 0–7.6%), although the values did not reach statistical significance.

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