CAT<sub>3</sub>, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O<sup>6</sup>-methylguanine DNA methyltransferase expression.

Onco Targets Ther · 2018 · PMC6026589 · PMID 29983575

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showed a trendno p-value reported

The tumors in the group treated with a combination of TMZ and CAT 3 showed a trend toward greatest reduction of tumor volume.

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