The effects of aging on neuropil structure in mouse somatosensory cortex-A 3D electron microscopy analysis of layer 1.

The density of multi-synaptic boutons, synapsing on spines, dendrites, or on both, was higher in adults, compared to aged mice, but did not reach statistical significance (MSBs on spines: 0.078 ± 0.02 per μm 3 adults; 0.065 ± 0.01 per μm 3 aged; t-test, p = 0.61; MSBs on dendrites: 0.0095 ± 0.004 per μm 3 adults; 0.0013 ± 0.001 per μm 3 aged; t-test, p = 0.09; MSBs on spines and dendrites: 0.025 ± 0.014 per μm 3 adults; 0.0045 ± 0.031 per μm 3 aged; t-test, p = 0.21).

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