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Peroxisome proliferator-activated receptor gamma agonist as a novel treatment for interstitial cystitis: A rat model.

Investig Clin Urol · 2018 · PMC6028466 · PMID 29984341

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In addition, a large group from Kaiser Permanente Health demonstrated a possible dose dependent increased risk of bladder cancer with prior pioglitazone use however this did not reach statistical significance [ 20 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.