Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro.

A decline in CFU was seen sequentially with increasing passage number ( Figure 4(d) ); comparison of CFU at p1 and p3, p3 and p5, and p1 and p5 was performed using Wilcoxon matched-pairs t - test and the difference was highly significant for each analysis ( p < 0.0001).

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The effect attributable to disease duration did not reach statistical significance ( p = 0.063), and there was no difference in β-galactosidase expression between samples isolated from patients with primary or secondary progressive disease.

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