showed a trendp = 0.08
When stratifying by age cohort, IgM and IgG4 were higher in infants (1.5–3 months) from Manhiça compared to Kintampo (p = 0.003 and p = 0.042, respectively), and total IgG, IgG1 and IgG3 showed a trend in the same direction (p = 0.08, p = 0.09 and p = 0.08, respectively) (Fig. 4B ).