Effect of Pioglitazone in Combination with Moderate Dose Statin on Atherosclerotic Inflammation: Randomized Controlled Clinical Trial Using Serial FDG-PET/CT.

Although a reduction in the FDG uptake by pioglitazone on top of atorvastatin in carotid arteries with a plaque was nearly statistically significant in the entire patients, pioglitazone showed a marked reduction of the FDG uptake of the vessels in the patients who had a baseline FDG uptake above the median.

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Conclusions Pioglitazone demonstrated marginally significant anti-inflammatory effects in addition to moderate dose atorvastatin.

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The difference of carotid TBR by the addition of pioglitazone was smaller (ΔTBR=0.04) than we expected from the previous FDG-PET/CT trial examined pioglitazone 12) and showed marginal significance.

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