Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia.

Int J Mol Sci · 2018 · PMC6032407 · PMID 29848961

Europe PMC DOI

hedged sentences

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

showed a trendp = 0.075so close (0.05 < p ≤ 0.1)

Furthermore, while Q14 and Q15 showed a trend to mediate higher calcium influx ( p = 0.075 and p = 0.085, respectively), Q16 exhibited a significant ( p ≤ 0.001) higher calcium mobilization when compared to MK-0677 (see Figure 4 A).

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failed to reach significanceno p-value reported

Exposure to quinolones Q15 and Q16 also showed an increased intracellular calcium mobilization upon pre-treatment with the SP-analogue but failed to reach significance (see Figure 3 B).

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