The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.

EMBO Mol Med · 2018 · PMC6034131 · PMID 29844217

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In contrast, metformin had no effect on cytokine‐induced atrophy and showed a trend toward smaller widths when used alone (Fig 1 C).

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