Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/progenitor cells.

Downregulation of SOX9 expression by the corresponding pathway inhibitors DMH1 (dorsomorphin homolog 1), DAPT (γ-secretase inhibitor) and cyclopamine was observed but did not reach statistical significance.

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Following siRNA-mediated knockdown of SOX9 in primary human LEPCs (n = 3), we observed a partly significant increase in expression levels of WNT4 and CTNNB1 , and a highly significant decrease in the expression levels of GSK3B up to 96 hours post-transfection compared to scramble siRNA-transfected controls (Fig. 7A ).

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