High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.

Among MS patients, highly significant deviations from HWE were seen for genotypes of DR~DQ haplotypes (p = 0.0027).

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Both Bw4T and Bw4I are in negative LD with DRB1*15:01 (d’ ij = -0.45 and -0.64 in cases, and -0.79 and -0.92 in controls, respectively) but the negative association of Bw4T with MS remains nominally significant (OR = 0.071; p = 0.032) even in the DRB1*15:01 negative stratum ( Table 7C ). 2.5.2 HLA Ligand with KIR Since the interaction of specific receptors and their HLA ligands is functional, we analyzed specific combinations of HLA ligands and KIR genotypes ( Supplementary Table S4A ).

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