A similar responsive pattern was also presented in the group treated with NMPP for 24 hours (a-c), which however, did not reach statistical significance (p = 0.15 and p = 0.07 by two-way ANOVA for ACh and NONOare-induced dilations, respectively), implying that a time-dependent treatment was required to observe this action of NMPP.
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Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling.
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