Although we could not detect any differences in total lymphocyte amounts between il10 e46/e46 and WT zebrafish, our qPCR analysis on the unsorted kidney cell samples showed a trend of elevated cd4-1 expression in il10 e46/e46 mutant fish compared to WT controls at 4 wpi and a significantly higher expression at 8 wpi.
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Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection.
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