Optimising first- and second-line treatment strategies for untreated major depressive disorder - the SUN☺D study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial.

Another recent RCT examined the value of switching escitalopram to venlafaxine if patients have shown minimal improvement after 2 weeks; remission rates were 8% higher in the switched than in the continuation arm, but this difference did not reach statistical significance, possibly due to a small sample size ( n = 192, p = 0.21) [ 51 ].

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