The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence.

Transl Psychiatry · 2018 · PMC6045574 · PMID 30006604

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

showed a trendp = 0.09so close (0.05 < p ≤ 0.1)

Association analyses in the NIAAA sample showed a trend-level relationship between rs10514299 and a lifetime AD diagnosis in the European American subgroup (odds ratio = 0.82, p = 0.09).

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marginally significantno p-value reported

Interestingly, our data showed a marginally significant protective effect of rs10514299 for AD, while Hyde et al. 10 identified the minor allele T as conferring risk for MDD.

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