No Significant Role for Smooth Muscle Cell Mineralocorticoid Receptors in Atherosclerosis in the Apolipoprotein-E Knockout Mouse Model.

SMC-MR deletion does not significantly alter aortic root plaque size, plaque composition, or vascular inflammation after 16 weeks of HFD feeding Histologic analysis of the aortic roots of MR-Intact and SMC-MR-KO ApoE −/− mice fed HFD for 16 weeks revealed a trend toward a reduction in plaque area (Figures 5A,F left, p = 0.0503) in mice lacking SMC-MR, though this did not reach statistical significance.

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