Patent foramen ovale and cryptogenic stroke: diagnosis and updates in secondary stroke prevention.

Stroke Vasc Neurol · 2018 · PMC6047340 · PMID 30022802

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showed a trendno p-value reported

26 The CLOSE study was underpowered to detect a difference in stroke recurrence risk between AC-only and AP-only groups; however, both the ITT and per-protocol analyses showed a trend towards lower rates of recurrent stroke at 5 years in the AC group.

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