Use of a novel camelid-inspired human antibody demonstrates the importance of MMP-14 to cancer stem cell function in the metastatic process.

There were no significant effects on E-cadherin, fibronectin, vimentin, twist-1, or snail-2 mRNA expression, although snail-2 showed a trend towards reduced expression with IgG 3A2 treatment ( Supplementary Figure 7 ).

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While there was a highly significant negative impact of 3A2 on tumor growth using both measures, the difference between the two modes of assessment highlights inaccuracies in both methods.

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