Extremely significant differences were found in the mRNA expression levels of FSHR ( P = 0.001), IGF-1R ( P = 0.001), and CYP19A1 ( P = 0.001) between the 2.5% dose group and the control group ( P < 0.01), and no difference was found between the 2.5% dose group and the NOR group.
There were highly significant differences in the E2 and progesterone secretion between the NOR and POR groups ( P < 0.01).
Effect of dandelion extract T-1 on the mRNA expressions of follicle-stimulating hormone receptor, luteotropic hormone receptor, insulin-like growth factor 1 receptor, and CYP19A1 in granulosa cells Normal ovarian response group The mRNA expressions of FSHR, LHR, IGF-1R, and CYP19A1 of GCs after the addition of DE-T1 showed an increasing trend in the NOR group compared with the control group.
Granulosa cell changes in patients with low responses after the addition of dandelion extract T-1 in vitro , followed by culture for different days After 1 and 2 days of culture of the GCs from patients with low responses with DE-T1 in vitro , the GCs showed a trend of slow proliferation over time.