Identified metabolites showing a sex‐specific response to 17aE2 We further assessed changes in individual known metabolites with 17aE2 treatment, again focusing on metabolites that change specifically in males but not females, as indicated by a significant two‐way interaction between sex and treatment, and also showing a nominally significant response to 17aE2 in males.
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Male lifespan extension with 17-α estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice.
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