Overexpression of CYB5R3 and NQO1, two NAD⁺ -producing enzymes, mimics aspects of caloric restriction.

RedTg mice showed a trend toward higher RER during the first (night‐fed, light‐fed), and these differences increased significantly at the third (refed) cycle (Figure 1 e), indicating that RedTg mice preferentially used carbohydrates to meet their energy needs as compared to Wt animals.

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