Expression of p16<sup>INK</sup><sup>4a</sup> is a biomarker of chondrocyte aging but does not cause osteoarthritis.

Aging Cell · 2018 · PMC6052464 · PMID 29744983

Europe PMC DOI

hedged sentence

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

a strong trendp = .054so close (0.05 < p ≤ 0.1)

Expression of several SASP markers showed a positive correlation to p16 INK4a levels despite no correlation to age: insulin‐like growth factor binding protein 3 ( IGFBP3 , r 2 = .0971, p = .018), matrix metalloproteinase 1 ( MMP‐1 , r 2 = .1247, p < .01), and a strong trend for MMP‐13 ( r 2 = .0667, p = .054).

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