Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro.

Sci Rep · 2018 · PMC6053382 · PMID 30026496

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.3640

boldest claim

The sentences

marginally significantp = 0.053so close (0.05 < p ≤ 0.1)

The DCS group also showed a marginally significant difference in mBFR when compared to the NoStim group (one-way ANOVA, p = 0.053; Fig. 6D , right panel), with a similar trend to the other measures of synchrony as described above.

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an increasing trendp = 0.364not close (p > 0.1)

The DCS group showed an increasing trend with respect to event synchronization (one-way ANOVA, p = 0.364) and cross-correlation peak (one-way ANOVA, p = 0.665) measures of synchrony when compared to the NoStim group (Fig. 6D ), although, no significant group differences were observed.

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showed a trendno p-value reported

Similarly to LFS, we observed that DCS following L-glutamate treatment showed a trend of increased excitability (Fig. 4C ; # of bursting cells) and a clear, although non-significant, increase in rate of maturation in synchrony (Fig. 4D ; Cross-correlation peak and mBFR) as well as increased BDNF and RAB3A expression.

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