Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis.

A further annotation with highly significant association (integrative FDR < 2%) and P < 0.05 on each one of the omics levels was endodermal cell differentiation ( Table 2 ).

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Moreover, for both gene expression and protein abundance levels, of the genes significant at 0.1% FDR in a given comparison (osteophytic/low-grade or osteophytic/high-grade), ⩾99.5% show the same direction of change in the other comparison and ⩾90% are at least nominally significant.

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