The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats.

BMC Biotechnol · 2018 · PMC6056991 · PMID 30041697

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closest p · 1.2× alpha

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The sentences

approached significancep = 0.06so close (0.05 < p ≤ 0.1)

There were no significant effects of NicA2 on response rate, although the higher response rate following saline versus 0.4 mg/kg nicotine and following 0.1 mg/kg nicotine + NicA2 versus 0.1 mg/kg nicotine + vehicle approached significance ( p = 0.06 and 0.07, respectively).

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