Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1.

No significant differential methylation of MAPT Analysis of the region 17q21.31 that spans 1.6 Mb (43,470,000 to 45,061,000 on chromosome 17) and includes MAPT revealed nominally significant methylation differences at 11 sites.

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While methylation differences only affect one or a few sites at most genes, highly significant ( ≥ 5%) hypermethylation is found at multiple sites associated with the gene DLX1 .

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