Intrathecal B Cells in MS Have Significantly Greater Lymphangiogenic Potential Compared to B Cells Derived From Non-MS Subjects.

We observed mild, but highly significant correlations between MS-DSS and three correlated cytokines, IL-1β, TNF-α, and GM-CSF (Figure 5 ).

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When we normalized cytokine production per 1 million of live, EBV-transformed CSF B cells we observed lower secretion of IL-10 in BCL derived from RRMS patients compared to non-inflammatory controls (difference between means [DM] = 164.7 pg/mL), but it did not reach statistical significance after adjusting for multiple comparisons (Figure 4A ).

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