Serum levels of B-cell activating factor of the TNF family (BAFF) correlate with anti-Jo-1 autoantibodies levels and disease activity in patients with anti-Jo-1positive polymyositis and dermatomyositis.

The negative association of serum levels of BAFF ( r = −0.55, p = 0.002, n = 30) as well as marginally significant negative association of anti-Jo-1 levels ( r = −0.35, p = 0.06, n = 30) with disease duration was documented in early patients.

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Between the first two samplings, a significant reduction in myoglobin (median from 94 to 62.8 μg/l; p = 0.001) and a borderline significant drop in CK (from 2.62 to 1.22 μcat/l; p = 0.07) in the total group was recorded, as well as a significant decrease in other muscle enzymes (LDH, ALT, and AST; p < 0.05) in the early patient group.

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The changes in BAFF were associated with ΔCK, Δmyoglobin, ΔALT, and ΔAST, and showed a trend to association with Δcutaneous, Δmuscle, Δglobal, and Δskeletal disease activities (Table 3 and Additional file 5 , left panel).

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