Genetic selection of athletic success in sport-hunting dogs.

We also noted that NAALAD2 , a member of the N -acetylated alpha-linked acidic dipeptidase (NAALADase) gene family whose inhibition results in a reduction in aggressive behavior ( 45 ), showed significant signatures of selection (XP-EHH, ∆ π , ∆ r 2 ) in the terrier breeds tested, despite lacking a highly significant SNV ( P < 5 × 10 −8 ).

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We observed a significant trend (slope >0, R 2 = 0.77) ( Fig. 5 ), such that breeds with a higher frequency of the advantageous A allele were likely to earn more titles at agility events than those with a lower frequency of this allele.

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