Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study.

In a study based on the Swedish Twin Registry with 43 years of follow-up, where dementia was assessed through electronic health records, a quadratic association was found whereby both no alcohol consumption and high alcohol consumption were associated with an increased risk of dementia, although the excess risk in abstainers did not reach statistical significance and the excess risk of high consumption began at 12 g/day (corresponding to around 10.5 units/week). 37 The study also found, as in our investigation, a reduced risk of dementia for moderate wine consumption and a linear increased risk of dementia in those consuming spirits.

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