Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression.

Recently, highly significant differences in DNA methylation have been observed among individuals exposed to tobacco smoke ( Joehanes et al. 2016 ; Joubert et al. 2012 ; Shenker et al. 2013 ; Zeilinger et al. 2013 ).

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We found numerous nominally significant novel DMCs at or nearby 450K array-derived, widely replicated smoking-associated locations in or near GFI1 , ALPPL2 , AHRR , MYO1G , SLC24A3 , PPP1R15A ( GADD34 ), and F2RL3 genes (listed in Excel Table S5) and at previously unknown smoking-associated locations in or near HOXA5 , RDX , and LRP5 .

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