Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy.

However, when normalized to protein input, mass spectrometric analysis of purified myelin demonstrated a highly significant reduction by >50% of nearly all classes of lipids in CMT rat myelin (Fig. 5c ).

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Importantly, after PL therapy, the lipid-to-protein ratio in the myelin of CMT rats showed a strong trend toward normalization, although the majority of individual lipid classes does not reach significance compared with non-treated Pmp22 transgenic controls (Fig. 5c ).

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