Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum.

The effect of LCA on the ileal Cyp24a1 induction was abolished in the Vdr(−/−) mice, similar to the effect of 1,25(OH) 2 D 3 , although the effect of 1,25(OH) 2 D 3 and LCA on the ileal Cyp24a1 expression did not reach statistical significance because of a large variation ( Figure 4 A).

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