Novel t(7;10)(p22;p24) along with NPM1 mutation in patient with relapsed acute myeloid leukemia.

Gene targeting and overexpression studies demonstrated the importance of clustered homeobox (HOX) gene in hematopoiesis, and substantial evidence exist to suggest that the aberrant expression of HOX gene contributes to the pathogenesis of leukemia, 13 which is the most frequently deregulated gene in T-ALL 14 by t(7;10)(q35;q24) and t(10;14)(q24;q11) and showed a trend for better outcome for patients. 15 Chromosomal translocation involving 10q24 region was also reported in B cell lymphoma where rearrangement of NFKB2, which is involved in the initiation or acceleration of tumorigenesis, was reported as a result of translocation t(10;14)(q24;q32) 16 and was associated with poor prognosis.

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