Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and <i>ex vivo</i> studies.

Aging (Albany NY) · 2018 · PMC6075434 · PMID 30048243

Europe PMC DOI

hedged sentences

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

marginally significantp=0.062so close (0.05 < p ≤ 0.1)

The skin & blood clock provides marginally significant evidence (p=0.062) that fibroblasts from boys with classic HGPS are epigenetically older than those from girls with classic HGPS, but this gender effect is not apparent when classic and non-classic HGPS samples are pooled for analyses ( Supplementary Figure 10 ).

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a significant trendno p-value reported

Essentially it highlights a significant trend of accelerated epigenetic aging with sub-clinical indicators of poor health.

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