Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program.

Nominally significant interaction was observed with respect to the cardiovascular death or hospitalized HF outcome for several subgroups, including patients with higher versus lower body mass index, lower versus higher baseline glycohemoglobin, with versus without background use of diuretic therapy, and with versus without background metformin use (all P interaction >0.02; Figure 3 ).

also in 7,732 other papers

The relatively few primary outcome events recorded limits the capacity to detect effects and makes difficult interpretation of borderline significant findings (eg, the interactions of canagliflozin treatment and HF prevention with baseline characteristics, such as obesity and use of some drug therapies).

also in 11,409 other papers