TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31.

Hum Mol Genet · 2018 · PMC6077813 · PMID 29860333

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did not reach statistical significanceno p-value reported

TSPO levels were also significantly increased by 35% in the striatum and 22% in the hippocampus in 9-month-old BACHD mice versus age-matched WTs; the increase in the cortex did not reach statistical significance ( Fig. 7D–F ).

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