<i>In Vivo</i> Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator.

Front Pharmacol · 2018 · PMC6079191 · PMID 30108503

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showed a trendno p-value reported

In mGlu5 -/- mice treated with vehicle, InsP levels were significantly reduced in the striatum and showed a trend to reduction in the prefrontal cortex and hippocampus, as compared to their wild-type counterparts ( Figure 3 ).

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