Although Ucp1 mRNA was significantly lower in Cited4 −/− males, Ucp1 protein only showed a trend of reduction, which could be due to the weaker correlation between Ucp1 mRNA and protein in male compared to female mice (Figs 4 C and D, and EV3 B; Appendix Fig S4A ).
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Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.
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