The basic character of the catalytic residue (H142) in the WT enzyme may be significant enough to be approximately comparable to that of a glutamate in this specific microenvironment.
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Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase.
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The sentences
The non-glyc-HS2ST demonstrated a clear trend in which the affinity increased according to the degree of HS sulfation.