A Major Mycobacterium tuberculosis outbreak caused by one specific genotype in a low-incidence country: Exploring gene profile virulence explanations.

Sci Rep · 2018 · PMC6082827 · PMID 30089859

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a clear trendno p-value reported

In fact, there was a clear trend towards strong purifying selection (decrease in dN/dS ratio) over the last thousand years (Fig. 1B ).

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