RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance.

Vimentin, a well-established marker of EMT [ 30 ], was robustly and significantly upregulated in the PC3-DR cells compared to sensitive PC3 but its upregulation did not reach statistical significance in DU145-DR cells compared to sensitive DU145.

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However, the P values were <0.01 for most of the DNAJC12, FABP5, and BOP1 datasets, indicating that upregulation of these transcripts is highly significant in PCa tissues compared to normal tissues.

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