Epigenetic modification of mesenchymal stromal cells enhances their suppressive effects on the Th17 responses of cells from rheumatoid arthritis patients.

In contrast, the A2V5- and A2V10-treated epi-hMSC cocultures had higher proportions of CD25 high Foxp3 + CD4 + T cells than the cultures under the Th17 conditions alone or with the untreated hMSCs, although the differences did not reach statistical significance (Fig. 5b ).

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