B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells.

We also found two-fold fewer long-lived E4 + AFCs in mice receiving Sle1b .IFNαR1 −/− .HKIR B cells than Sle1b .HKIR B cells 30 days after B cell transfer ( Figure 4I ), although the difference did not reach statistical significance due to an outlier in each group.

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