R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass.

At 6 months of age, male mice also had significant reductions in the maximum load force and bending stiffness, while the μCT data only showed a trend toward reduction in cortical bone mass.

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While cortical BV and cortical thickness still showed a decreasing trend in the Ocn-Cre + Rspo2 f/f mice at 6 months, these parameters were no longer statistically significant (Supplementary Figures S3F,I ).

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