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Effects of Anti-Integrin Treatment With Vedolizumab on Immune Pathways and Cytokines in Inflammatory Bowel Diseases.

Front Immunol · 2018 · PMC6090141 · PMID 30131801

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In CD patients, a significant reduction of α4β7 expression on Th2 and Th17 lamina propria CD4 + T cells was likewise observed in VDZ remitters compared with CD non-remitters, whereas the reduction of α4β7 expression on Th1 polarized CD4 + T cells did not reach statistical significance (Figure 3 E).

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