When both NHOF-1 and NHOF-5 were combined and their zero time controls compared with their corresponding levels at day 20, 39 metabolites were significantly altered but the previously reported citrate only showed a strong trend, because of a large outlier in the NHOF-1 control group (Supplementary Table S1A ).
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The induction of the fibroblast extracellular senescence metabolome is a dynamic process.
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