A significant trend of increasing HRs along with elevated ferritin levels was observed (P for trend <0.0001).
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Ferritin level prospectively predicts hepatocarcinogenesis in patients with chronic hepatitis B virus infection.
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The association was still significant after adjusting for age, gender, smoking status, drinking status, and family history of cancer (HR=1.76, 95% CI, 1.16–2.65) and became borderline significant when cirrhosis and AFP were further added to multivariate adjustment (HR=1.45, 95% CI, 0.96–2.19).