Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor.

At the end of the 22-week observation period, the number of tumors in the WT AR group was reduced by 55% compared to the WT R group, and this reduction was statistically significant, whereas tumor incidence was decreased by less than 18% between the TKO AR and TKO R groups, and this decrease did not reach statistical significance as was determined by two-way ANOVA ( Figure 1 , A and C ).

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