Exposure-safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate.

Acta Neurol Scand · 2018 · PMC6099471 · PMID 29732549

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showed a trendno p-value reported

3.4 Exposure‐response relationships for serum sodium There was no apparent trend in serum sodium concentrations over time in the placebo group, while some patients in each of the ESL groups (particularly the highest dose group) showed a trend for decreasing serum sodium concentrations over time (data not shown); these patients were considered outliers.

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